ABSTRACT
Background: Around one and half years ago in the December of 2019 a flu like disease emerged in the city Wuhan located in China. This was termed by WHO as a global pandemic due to its rapid widespread. Aim: To compare the efficacy of high dose dexamethasone (8 mgx tds) vs low dose methylprednisoslone (100 mgx bd) therapy for two weeks, in resolution of acute inflammatory markers in patients with covid pneumonia. Study Design: Quasi experimental study. Methodology: Patients (n=72) with an age range of 18-70 years with Covid 19 PCR positive having Covid associated pneumonia were enrolled. Group 1 containing 36 patients receiving high dose dexamethasone (8 mgx TDS) and group 2 with 36 participants receiving low dose methylprednisolone (100 mgx BD). Inflammatory markers (CRP, ESR and Ferritin) were recorded on Day 1 (T1) on day 7 (T2) and day 14 (T3). Patients who required ventillatory support and those who died was also recorded.All this information was recorded on Performa. Data was analyzed using SPSS version 26. Results: Mean age of the patients was 50.11±11.7 years. When we compared the inflammatory markers among group 1 and group 2 at T1, T2 and T3 no statistically significant difference was obtained. Conclusion: It was concluded that high dose dexamethasone and low dose methylprednisoslone therapy for two weeks were equally effective in resolution of acute inflammatory markers in patients with covid pneumonia.
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Background: The Covid-19 pandemic has wreaked havoc throughout the world, with 150 million cases to date and over 3 million lives claimed worldwide. Aim: To explore the hypoxemia in COVID-19 patients in relation with genomic mutation and co-morbidities. Study Design: Experimental Study. Methodology: A total of 16 COVID-19 positive patients admitted to Aziz Bhatti hospital were included in this study. COVID-19 was confirm through nasopharyngeal swab specimen diluted in normal saline subsequent RT-PCR was performed as per the standard operating procedure. Genome sequencing and interpretation of analysis was done through Illumina MiSeq. Results: There was statistically significant difference (P < 0.05) in SaO2 in patients with N (Nucleocapisd) protein mutation compared with NSP13(Helicase) mutation. Conclusion: It was concluded that mutation of N (Nucleocapisd) protein causes more pronounced hypoxia compared with Helicase mutation of COVID-19 genome.
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Background: The Covid-19 pandemic has wreaked havoc throughout the world, with 150 million cases to date and over 3 million lives claimed worldwide. Aim: To explored the difference in levels of SaO2 of COVID-19 positive patients with and without COPD. Study design: Experimental Study. Methodology: From May2020 to 2021 patients admitted at Aziz Bhatti Shaheed hospital were included in this studies. COVID- 19 was confirmed by RT-PCR.COPD was confirmed by using GOLD standard of diagnostic criteria. SaO2 was measured by using pulse oximeter and confirmed by blood samples measurement of SaO2. Statistical analysis: SPSS version 22 was used for data analysis. Paired sample t test was performed to evaluate the hypoxia levels between three pairs among the time distribution of 1st, 3rd, and 6th, day. Results: Levels of SaO2 were statistically significant between COVID-19 positive patients and COVID-19 positive patients with COPD. We calculated the levels of SaO2 at day1, 3rd, and 6th day and results were significant to show that COPD might be having some protective effect against hypoxia and that might be due to use of medications or adaptation of pulmonary cells. Conclusion: It was concluded that levels of SaO2 was significantly reduced in COVID-19 patients without COPD in comparison to patients without COPD.
ABSTRACT
The Covid-19 pandemic has wreaked havoc throughout the world, with 150 million cases to date and over 3 million lives claimed worldwide Objectives: To assess the immediate side effects of Covid-19 vaccination among the people of Pakistan Study Design: Randomized, descriptive cross-sectional study Methodology: Present study was carried out using an online questionnaire by enrolling 17040 subjects. Inclusion/Exclusion criteria: All citizens of Pakistan over the age of 12, who were eligible for the COVID-19 vaccination were enrolled. Statistical analysis: Data was analyzed by SPSS software, version 25 in terms of frequencies and percentages. Results: In present study, results showed that 76% subjects were vaccinated. Among them 64% received Sinopharm, 30% Sinovac, 0.7% Pfizer, 0.5% Astrazeneca, 2.8% Moderna, 0.8% Cansino, 0.3% PakVac and 0.1% Sputnik V. Most participants (66%) suffered no symptoms post vaccination. Only 15% developed fever, 7% dizziness, 5% vomiting, 4% pain at injection site, 2% headache and 1% fatigue. After vaccination, 1% had a reinfection and 99% so far have not caught Covid-19. Among all participants, 87% found the vaccine safe, 7% were neutral and 5% found it unsafe. Conclusion: We concluded that most Pakistanis have received the Chinese vaccine i.e. Sinopharm. Majority individuals have experienced either no to mild or few moderate type of adverse effects following immunization irrespective of the age and gender that can be easily managed at home.
ABSTRACT
The whole world is suffering from COVID-19 pandemic. This disease has halted life and has a negative impact on physical and mental health of all individuals. Objectives: To identify impact of BMI on Covid-19 clinical features and its management in terms of relationship among patients at government hospitals, Pakistan. Study Design: Cross-sectional study. Methodology: This study enrolled 206 patients having both genders and was carried at Life Diabetes Centre, Gujrat and CMH Kharian Medical College (CKMC), over a period of 3 months, Kharian-Pakistan following ethical review committee's (ERC) approval. Statistical analysis: Data was analyzed by SPSS software, version 17. Parameters like age, gender and treatment taken were presented as frequency. Chi square was applied to see the correlation with p-value <0.05 as significant. Results: Total 206 patients were randomly selected, 89 male and 117 females. Among 206, patients (n=133) showed symptoms while rest of the patients (73) remained asymptomatic. There was no association of BMI with COVID-19 symptoms having P-value greater than 0.05. There was an association of BMI with gender as P-value (0.000*). There was an association of BMI with age having P-value (0.000*). Conclusion: From present study, we concluded that there was a correlation between BMI and individuals with higher BMI as they developed more serious symptoms and required active management strategies in comparison to individuals who were either underweight or normal weight.
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Background: The lockdown due to Covid-19 has impacted certain aspects of cognition among medical students. Aim: To explore the impact of the Covid-19 lockdown on metamemory among medical students studying in a private medical college in Pakistan. Study design: Experimental study. Methodology: This study with enrolled students (n=233) was carried out after ethical review committee's (ERC) approval at CMH Kharian Medical College (CKMC), Physiology Department, Kharian-Pakistan. Both male and female medical students were enrolled. In phase 1, the students reported to the Physiology laboratory where age and gender were recorded. Metamemory was measured using the Multi-factorial Memory Questionnaire (MMQ)Satisfaction scale using the Baycrest Centre protocols for its administration and scoring. Data was analyzed by SPSS software, version 21. MMQ-Satisfaction score was presented as mean +/- SD. Statistical significance was taken at p value <0.05. Results: Among males mean +/- SD for Pre Covid-19 MMQ was 43.24 +/- 9.58 while mean +/- SD for Post Covid-19 MMQ males was 55.32 +/- 6.01. Significant difference was seen between Pre & Post Covid-19 MMQ scores with p-value of <0.000. Conclusion: We concluded that significant difference was seen between Pre & Post Covid-19 MMQ scores with p-value of <0.000. However, means among all age groups were significantly equal with the others in Pre & Post COVID-19 MMQ. Similarly, means were significantly equal among both genders for Pre & Post COVID19 MMQ.
ABSTRACT
Background: The whole world is facing one of the biggest health related disaster (COVID-19) of the century. Aim: To identify age and gender-based differences in Covid-19 clinical features and its management among patients at government hospitals, Pakistan. Study design: Cross-sectional study. Methodology: This study with enrolled subjects (n=206) was carried out after ethical review committee's (ERC) approval at Life Diabetes Centre, Gujrat and CMH Kharian Medical College (CKMC), over a period of 3 months, Kharian-Pakistan. Both male and female medical subjects were enrolled. Statistical analysis: Data was analyzed by SPSS software, version 17. Parameters like age, gender and treatment taken were presented as frequency. Chi square was applied to see the correlation with p-value <0.05 as significant. Results: Total 206 patients were randomly selected, 89 male and 117 females. Among 206, patients (n=133) showed symptoms while rest of the patients (73) remained asymptomatic. There was no association of age and gender with COVID-19 symptoms having P-value greater than 0.05. There was a significant association between treatments given was significantly related with age having P-value (0.006*). Conclusion: We concluded that there was no strong association between age and gender-based differences in Covid-19 clinical features;this could be due to small sample size.
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Background: The whole world is facing one of the biggest health related disasters of the century. As a novel disease, Covid-19 has so many parameters yet to explore. Aim: To explore varied pattern of clinical presentation of COVID-19 in obstetric population in tertiary care hospital. Study design: Cross-sectional study. Methodology: This study with enrolled pregnant females (n=36) was carried out after ethical review committee s (ERC) approval at Department of Gynecology & Obstetrics, Sir Ganga Ram Hospital, Lahore-Pakistan over a period of 3 months in 2020. Data was analyzed by SPSS software, version-20. Presenting symptoms of subjects were presented as frequency and percentage. Results: Total 36 patients were selected. Twenty four (66.66%) patients were symptomatic while the rest 12 (33.33%) patients were asymptomatic. Conclusion: We concluded that clinical presentation of COVID-19 pregnant patients is similar as in rest of the world and it is also same as in general population.
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The whole world is facing one of the biggest health related disasters of the century. As a novel disease, Covid-19 has so many parameters yet to explore. Objectives: To explore any correlation between atopy and Covid-19 among residents of Gujrat and Kharian, Punjab, Pakistan. Study Design: Cross-sectional study. Methodology: This study with enrolled subjects (n=206) was carried out after ethical review committee’s (ERC) approval at Life Diabetes Centre, Gujrat and CMH Kharian Medical College (CKMC), over a period of 3 months, Kharian-Pakistan. Both male and female medical subjects were enrolled. Statistical analysis: Data was analyzed by SPSS software, version 17. Parameters like gender, allergy and treatment taken were presented as frequency and percentage. Chi square was applied to see the correlation with p-value <0.05 as significant. Results: Total 206 patients were randomly selected, 89 male and 117 females. Among 206, only 13 patients had allergy from different allergens. Only 2 patients required hospitalization and injectable treatment. Conclusion: We concluded that there is strong affiliation between atopy and Covid-19 presentations.
ABSTRACT
The Covid-19 pandemic has wreaked havoc throughout the world, with 150 million cases to date and over 3 million lives claimed worldwide. Objectives: To explore the impact of the Covid-19 lockdown on psychological health parameters i.e. depression, anxiety and stress as well as on body mass index among medical students studying in a private medical college in Pakistan. Study Design: Experimental study. Methodology: This study with enrolled students (n=233) was carried out after ethical review committee’s (ERC) approval at CMH Kharian Medical College (CKMC), Physiology Department, Kharian-Pakistan. Both male and female medical students were enrolled. In phase 1, the students reported to the Physiology laboratory where age and gender were recorded. The pre-lockdown readings of BMI and DASS-21(Depression, Anxiety, Stress) scale were taken. In phase-2, the post-lockdown readings of BMI and DASS-21 scale were taken once the students returned to campus. Statistical analysis: Data was analyzed by SPSS software, version 21. BMI and DASS-21 score were presented as mean + SD. Statistical significance was taken at p value <0.05. Results: In present study, results showed that there was a decrease in level of depression post-Covid-19-lockdown among enrolled subjects with significant p-values (0.019*) in the pre and post covid-19-lockdown comparison. Conclusion: We concluded that significant difference was seen between Pre & Post Covid-19-lockdown depression with p-value of <0.019. However, insignificant difference was seen between Pre & Post Covid-19-lockdown anxiety and stress with p-value of >0.05. Key Words: Covid-19 lockdown, Medical students, Depression, BMI and Anxiety.